A Comparative Study of the Effect of Priming and Sevoflurane on Intubating time and Intubating Conditions with Rocuronium as Intubating Agent in Neurosurgical Patients.

ABSTRACT

Background: Rocuronium provides good intubating conditions but large doses causes prolongation of its duration of action, making it unsuitable for short surgical procedures. Aims: This study was designed to compare the effects of rocuronium with 3min priming interval and 2% sevoflurane on the time of intubation and intubating conditions. Methods: the study design is that of randomized, prospective double‑blind trial. Forty five adult patients were randomly allocated into three equal groups Group R received 0.8 mg/kg rocuronium, Group RS received 0.8 mg/kg of rocuronium with 2% sevoflurane andGroup RP patients received a priming dose of 0.08 mg/kg of rocuronium followed by 0.72 mg/kg rocuronium 3 min later. Onset time of intubation, intubating conditions and time for loss of thumb adduction were assessed. Analysis of variance (ANOVA) test was used to compare the demographic data and intubating conditions among the groups.Intergroup comparison between R and RS,R and RP,RS and RP of the time for intubation and time for the loss of thumb adduction were done using student t test. A P value <0.05 was considered significant. Results: The onset time of intubation (loss of T1 of TOF) was 100.53+2.03s in group 62.9+1.9 s in-group RS, and 61.88+1.9s in group RP. The time for the loss of thumb adduction in R,RS,RP were 98.53+2.03, 60.93+1.9, 60+2.12 respectively. There is statistical significance p=0.001 between R and RS ,R and RP group while comparing the onset time for intubation and time for the loss of thumb adduction. Mean intubating scores were excellent in all the three groups.Conclusion: Both rocuronium (0.08mg/kg) along with 2% sevoflurane and priming principle for rocuronium provide excellent intubating conditions within 60-66 sec in neurosurgical patients.