Potential for Osseous Regeneration of Platelet Rich Fibrin: A Comparitive Study in Mandibular Third Molar Socket.

ABSTRACT

Aims: To evaluate the effi cacy of autologous platelet- rich fi brin in regeneration of bone and to assess clinical compatibility of the material in mandibular third molar extraction socket. Materials and Methods: This study was conducted in 20 patients visiting the out patient department of Oral & Maxillofacial Surgery, Subbaiah Institute of Dental Sciences. Patients requiring extraction of bilateral symmetrical mandibular third molars were taken for the study. Following extraction, platelet rich fi brin prepared from patients own blood was placed in one extraction socket. The patients were assessed for postoperatively pain, periodontal pocket depth and bone blending and trabecular formation. Radiological assessment of the extraction site was done for a period of 6 months to evaluate the change in bone density. Results: All the local signs and symptoms of infl ammation were mild to moderate and subsided in normal course of time. Pain was less in study site compared to control site. Soft tissue healing was better in study site. Evaluation for bone blending and trabecular bone formation showed earlier in study (prf)site compared to control(non prf) site in 10 patients. The evaluation of bone density by radiological assessment showed the grey level values calculated at 4months at the prf site were comparatively higher than the average baseline value of bone density at extraction site in control site. Conclusion: The study showed that autologous PRF is biocompatible and has signifi cant improved soft tissue healing,bone regeneration and increase in bone density in extraction sockets. However a more elaborate study with a larger number of clinical cases is very much essential to be more conclusive regarding its effi cacy.