Hepatocellular Carcinoma Sub-types in North-Central Nigeria: A Histological Review of Liver Biopsies.
Br J Med Med Res
;
2016; 12(4): 1-8
Article
in English
| IMSEAR
| ID: sea-182207
ABSTRACT
Introduction:
Hepatocellular carcinoma (HCC) is the 6th most common cancer worldwide and a greater burden of this disease is born by the hepatitis B virus (HBV) endemic and resource deficient sub-Sahara Africa. This investigation was carried out to determine the pattern of hepatocellular carcinoma sub-types in north-central Nigeria. Materials andMethods:
Archival formalin fixed and paraffin embedded 374 liver biopsy specimen blocks were obtained, sectioned, re-stained and examined histologically. Classification of primary liver cancers was done according to standard World Health Organisation criteria.Results:
Chronic HBV infection was found in 219 (58.6%) and cirrhosis in 29 (7.8%) cases. HCC occurred in 76 (20.3%) cases with background cirrhosis in 18 (23.7%) of the HCC. The HCC subtypes found were the trabecular 54 (71.1%), acinar 10 (13.2%) and mixed trabecular and acinar 6 (7.9%), clear cell 5 (6.6%) and fibrolamellar 1 (1.3%) respectively.Conclusion:
HCC is the most common histologically diagnosed primary liver cell carcinoma with the trabecular subtype as the predominant variant in Nigeria, followed by the pseudoglandular and the mixed types.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Journal:
Br J Med Med Res
Year:
2016
Type:
Article
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