Reduced Vascular Endothelial Growth Factor A Levels are Correlated with the Incidence of Brain Edema in Acute Ischemic Stroke Patients.
Br J Med Med Res
;
2016; 13(2): 1-7
Article
in English
| IMSEAR
| ID: sea-182474
ABSTRACT
Aims:
To study the correlation between the vascular endothelial growth factor A/VEGF-A level and the incidence of brain edema in acute ischemic stroke patients. StudyDesign:
A prospective observational analytic case-control study. Place and Duration of Study Stroke Unit at the Dr. Sardjito General Hospital, Yogyakarta, Indonesia, between December 2010 and August 2011.Methodology:
Seventy-one hospitalized acute ischemic stroke patients were recruited, consisting of 37 subjects in the brain edema group and 34 subjects in the non-brain edema group. Comparative analysis of the VEGF-A levels in blood was performed between the brain edema and non-brain edema groups.Results:
The average level of VEGF-A in the brain edema group was 436 pg/mL and the one in the non-brain edema group was 746 pg/mL. This difference was statistically significant (95%CI 5.5-615; P=.046). The proportion of VEGF-A levels less than the calculated cut-off point (638.3 pg/mL) in the brain edema group were significantly greater than the ones in the non-brain edema (83.78% and 58.82%, respectively; OR=3.6; 95%CI=1.06-13.26; P=.020).Conclusions:
The decreased levels of VEGF-A in blood were correlated with the incidence of brain edema in acute ischemic stroke patients.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Incidence study
/
Observational study
/
Risk factors
Language:
English
Journal:
Br J Med Med Res
Year:
2016
Type:
Article
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