Association Between Indexes of Insulin Sensitivity/ Resistance and Serum Magnesium Levels in Overweight Diabetic Subjects.

ABSTRACT

Objective: To study the association of serum magnesium level and indexes of insulin sensitivity/resistance in overweight diabetic subjects and evaluate the relationship of serum magnesium level with body mass index (BMI) in overweight diabetic subjects. Study design: This case-control study was conducted on 50 overweight type 2 diabetic patients. The overweight diabetic subjects were defined as (BMI ≥ 25.0-30.0 kg/m2) according to the criteria of World Health Organization (WHO), 2004. Diagnosis of type 2 diabetes mellitus was made according to the criteria recommended by the American Diabetes Association standards - 2012. Material and methods: The study was conducted on 50 overweight type 2 diabetic patients of either gender attending/admitted in OPD/wards of the Dept. of General Medicine, Jawaharlal Nehru Medical College and Associated Group of Hospitals, Ajmer, Rajasthan over a period of 12 months. Results: In overweight diabetic subjects, serum magnesium level were found to be low, HOMA-IR was high and QUICKI values was found to be low in comparison to normal weight nondiabetics. Serum magnesium significantly inversely correlated with BMI, plasma glucose, HbA1C, serum insulin, HOMA-IR and a positive correlation of serum magnesium with QUICKI (overweight subjects) was found in our study. Conclusion: Poor glycemic control in hypomagnesemia patients has been observed in the present study when compared with normomagnesemia patients. Hypomagnesemia may aggravate insulin resistance state in overweight subjects. This can predispose them to metabolic complication of diabetes mellitus.