Use of Nifedipine and Isoxpurine Hydrochloride in Prevention of Preterm Labor - A Prospective and Comparative Study

ABSTRACT

Background: The study was done in Obstetric & Gynaecology   Department of Dr. VRK Women's Medical college to prevent the preterm labor which one is better either Nifedipine or Isoxpurine hydrochloride. Methods: In one month period total 1884 patients  attended OPD of Obstetric & Gynaecology. Out of 416 patients came with preterm labor.200 patients chosen for tocolysis.100 patients were given Nifedipine and 100 patients Isoxpurine hydrochloride. Results: Preterm labor incidence was 22% while preterm delivery incidence was 20.9%. Nifedipine was more effective than Isoxpurine hydrochloride for preterm labor whether it is diagnosed either in early stage or late stage. In early-diagnosed preterm labor, Nifedipine had higher efficacy than Isoxpurine (P value 6.45 × 10−6) and also higher efficacy than its own in late diagnosed preterm labor (P value 2.08 × 10−5). Conclusions: In  India preterm labor incidence is very high. So Nifedipine is better option than Isoxpurine hydrochloride especially when patient is having early signs of preterm labor.