Bacteriological Profile and Antibiotic Sensitivity Pattern in Community Acquired Neonatal Sepsis in Rajsamand – A Hospital Based Prospective Study

ABSTRACT

Background: To isolate the pathogenic bacteria and to know the antibiotic sensitivity in the community acquired neonatal sepsis. Materials & Methods: It was a prospective study undertaken on 120 neonates suspected of community acquired neonatal sepsis admitted in Pediatrics Department of AIMSRC over a period of twoyear. All these cases fulfilled the inclusion criteria required for the study. Blood culture of these cases was performed by Mackie and McCartney method and antibiotic sensitivity by Kirley-Baner’s disc diffusion method. Results: Out of 120 cases,88cases showed positive blood culture. Gramnegative isolates (N=55) were more frequent than gram positive isolates (N=33). Most common isolate was Klebseilla, Pneumoniae followed by Staphylococcus Aureus, E.Coli, Pseudomonas Aeroginosa, Acinetobacter. Both gram negative as well as gram positive isolates showed high resistance to ampicillin and gentamycin. Gram negative isolates were highly sensitive to Colistin Sulphateand Meropenem whereas gram positive isolates were highly sensitive to Linezolid andVancomycin. Conclusion: Gram negative bacteria were more frequent causes of community acquired neonatal septicemia than gram positive isolates. Both gram positive and negative isolates showed poor sensitivity towards conventional first line antibiotics, rather were mainly susceptible to higher antibiotics. So,the knowledge of the pattern of bacteriological isolates and their antimicrobial susceptibility pattern can be very helpful for prompt treatment of such patients, to decrease neonatal morbidity and mortality as well as reducing the emergence of multi-drugresistant organisms.