Comparative Evaluation of Efficacy of Clindamycin and Trimethoprim - Sulfamethoxazole for Treating Patients with Uncomplicated Skin Infections

ABSTRACT

Background: The most common bacterial causes of skin and soft tissue infections (SSTI) are group A Streptococcus (GAS) and Staphylococcus aureus, the key bacterial agents of impetigo, cellulitis, abscesses, and wound infections. Aim of the study To compare efficiency of clindamycin and trimethoprim-sulfamethoxazole for treating patients with uncomplicated skin infections. Materials & Methods: The study was conducted in the department of general medicine of the Government S.K. Hospital, Sikar, Rajasthan, India. . For the study we selected subjects from the surgical ward of the hospital of the medical institute. The patients diagnosed with uncomplicated skin infection were included in the study. A total of 42 patients were selected for the study. Results: A total of 42 patients were enrolled, 21 in group 1 and 21 in group 2. We observed that clinical cure at 17-20 days was 78.03 % in Group 1 and 74.31 % in group 2. Clinical cure at one month follow up was 71.22% in group 1 and 65.21% in group 2. Clinical cure in adults in group 1 was 76.2% and in group 2 was 74.84%. Clinical cure in pediatrics was 83.29% in group 1 and 79.35% in group 2. Clinical cure rate of abscess for group 1 was 77.96% and for group 2 was 81.21%. Conclusion: Within the limitations of the study we conclude that both the drug combinations i.e., clindamycin and trimethoprim-sulfamethoxazole are equally effective in treating uncomplicated skin infections.