Intravenous Iron Therapy for the Treatment of Iron Deficiency Anemia: Ferric Carboxymaltose Vs Iron Sucrose

ABSTRACT

Background: Postpartum anemia effects every fourth women in India. Parenteral iron therapy in comparison to oral is much faster in correction of Hb level, and replenishment of iron stores with much better compliance.  The two available preparations of parentral iron that is iron sucrose and ferric carboxymaltose were compared in the present study for safety and efficacy. Methods: This prospective observational study was conducted in the department of  obstetrics and gynecology (SRHU Dehradun Uttarakhand)  for a period of 18 month.  180 women of iron deficiency anemia were divided into two groups. 100 mg of IV iron sucrose was given in multiple dose of 200mg on alternate day over a period of 10 days to one group. 1000 mg of IV ferric carboxymaltose was given a single dose to the 2nd group of 90 women. side effects and reactions were noted. Results: Hb% and serum ferritin were done after 14 day of last injection the mean rise in HB in both groups were 1.71%( Group I) versus 3.20 % (Group II)     serum     ferritin     levels    was     found  significantly higher (p vol < 0.0001) in group II there were no serious adverse reactions in either group. Conclusions: FCM proved its efficacy better than iron sucrose. short stay at hospitals, large dose were given at over with very few adverse reactions were the main advantage.