A Comparative Study on Monotherapy with Metformin, Vit-B3, Vit- D, Chromium Piconilate and Lifestyle Modification in development of Type II Diabetes Mellitus in the Metabolic Syndrome Patients

ABSTRACT

Background: Metabolic syndrome is a combination of multiple risk factors that increases an individual chance of developing cardiovascular or type II diabetes mellitus and most of people with metabolic syndrome have Insulin resistance, which elevates the risk of developing Type II diabetes mellitus. While the pathogenesis of the metabolic syndrome and each of its components is complex and not well understood, central obesity and insulin resistance are acknowledged as important causative factors. Most scrutinized literature was collected from different sources including PubMed. This study was carried out at Govt. Chhattisgarh Institute of medical sciences Bilaspur. Aim: To compare the incidence of progression of metabolic syndrome into type II diabetes mellitus in patient who were put on one of the following treatments along with lifestyle modification- Metformin, Chromium Piconilate ,Vitamin –D3 and Niacin (Vitamin. - B3). Methods: The objective of this study recruited 250 patient, aged between 35 to 60 years, who fulfilled the inclusion and exclusion criteria of Metabolic syndrome as per study design. Results: 250 Participants was enrolled during 3 years of the study. 125 (50 %) male and 125 (50 %) Female were found metabolic syndrome. A total (8%) of patient were found incidence of progression of metabolic syndrome into Type II Diabetes Mellitus. In different group as Metformin group-(0%), Niacin group (6%), Vit-D3 group (0%), Chromium Piconilate group (16 %) and (18%) in the lifestyle modification group. Conclusions: Metformin and Vit- D3 can reverse the effects of metabolic syndrome due to its broad effects on many of the components of metabolic syndrome; thus preventing diabetes and heart disease.