Prevalence and Predictors of Metabolic Syndrome in Polycystic Ovarian Syndrome in Uttarakhand

ABSTRACT

Background: Woman with polycystic ovarian syndrome (PCOS) are at increased risk of developing Metabolic syndrome (MS). MS is a clustering of factors known to increase the risk of diabetes mellitus and cardiovascular disease. Aim of this present study was to determine the prevalence and predictors of MS in PCOS women of Uttarakhand. Methods: This prospective observational study was conducted in department of Obtstetrics & Gynecology, SHRU from May 2016 till May 2017. A total of 200 women, diagnosed with PCOS between the ages of 15-40years were involved (by Rotterdam’s criteria). Clinical and biochemical parameters for MS, were defined by National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. Statistical analysis were performed with descriptive analytical methods using SPSS software version 16. Results: The prevalence of MS in PCOS was 22  (44 cases). The rate of central obesity, FBS more than 110mg/dl, triglycerides more than 150mg/dl, high density lipoproteins cholesterol levels (HDL-C) less than 50mg/dl and blood pressure ≥130/85mmHg in PCOS women were 30  (60), 3.5 (7), 34 (68), 70 (140) and 11 (22), respectively.  PCOS has evolved as a risk factor for endocrinal and metabolic derangements. Conclusions: Special strategies are required to prevent MS and its associated complications in PCOS women.