A Comparative Study Of Propofol-Ketamine And Propofol-Fentanyl For Total Intravenous Anaesthesia For Short Surgical Cases In Paediatric Patients

ABSTRACT

Aims and objective:To compare combinations of Propofol-Ketamine and Propofol-Fentanyl for total intravenous anesthesia in short surgical cases in pediatric patients. The study also compared recovery characteristics and the incidence of side effects / complications in the groups. Methodology: The patients were randomly divided into two groups depending upon the drug combination used for Total Intravenous Anaesthesia. Group I 30 patients were given i.v. Ketamine followed by Propofol. Group II 30 patients were given i.v. Fentanyl followed by Propofol Recovery characteristics were compared and the incidence of side effects and complications in two groups were noted. Results: The pulse rate and blood pressure remained near to preinduction value in group I, while in group II these values decreased. After induction RR increased in group I but decreased in group II at 1,3%5 min after induction.None of the patients in both groups were observed to have nausea, vomiting and respiratory depression. . A significant no. of the patients in group II were observed to have either pain on injection site or restlessness. Conclusion: Propofol-Ketamine and Propofol-Fentanyl combinations provide satisfactory surgical conditions for minor surgical procedures in paediatric patients, but the Propofol-Ketamine combination gives better hemodynamic stability and less restlessness during induction and maintenance of anaesthesia.