Antioxidant And Free Radical Scavenging Effect Of Prucalopride : An Invitro Study
Article
| IMSEAR
| ID: sea-184836
ABSTRACT
Introduction:
Reactive oxygen species like superoxide radicals, hydroxyl radicals, singlet oxygen are implicated in causing tissue injury and cytotoxicity. They play a vital role in various diseases like ischaemic disease, degenerative disease and many more. Prucalopride is a novel drug used in chronic constipation that acts as selective, high affinity 5-HT4 receptor agonist which targets the impaired motility. This in-vitro study was done with an objective to evaluate additional radical scavenging property of the drug prucalopride. Materials andMethods:
In-vitro DPPH assay and Nitric oxide scavenging assay.Results:
The methanol extract of the drug Prucalopride showed free radical scavenging effect with DPPH at the concentration of 1000 μg/ml. And also an increase in nitric oxide scavenging effect was observed with increased concentration of drug.
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Index:
IMSEAR (South-East Asia)
Year:
2019
Type:
Article
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