A Prospective And Randomized Double Blind Study To Compare The Effectiveness Of Prophylactic Granisetron Versus Pethidine For The Prevention Of Postoperative Shivering In Patients Undergoing Elective Thyroid Surgeries

ABSTRACT

MATERIALS AND METHODS 90 Patients randomly allocated into three groups- qroup P, qroup G, qroup S in each group 30patientswere Selected Group P Patients were given Inj Pethidine 25 mg intravenously 5 minutes before induction of general anaesthesia. Group G Patients were given Inj Granisetron 40 microgram /Kgintravenously 5 minutes before induction of general anaesthesia. Group S Patients were given Saline intravenously 5 minutes before induction of general anaesthesia. RESULTS Postoperative shivering graded after extubation at 15 and 30 minutes interval no shivering in Pethidine group 83.3% {n= 25} Granisetron, qroup 73% {n=22} Placebo qroup 27% {n=8} P value not significant between P & G group but significant in Placebo qroup {P <0.05}. shivering occurs at grade 3in pethidine group 7% [n=2] Granisetron group 10%[n=3], Placebo group 60%[n=18] P value statistically not significant between P & G groups but significant in Placebo qroup {P <0.05}. CONCLUSION From this study prophylactic use of both Pethidine and Granisetron were equally effective for the prevention of postoperative shivering