Correlation Between The Parameters Of Diffusion Capacity Of Lung With Diabetic Nephropathy, A Hospital Based Study In Eastern India

ABSTRACT

Background. Diabetes mellitus is a systemic disease with complications involving eyes, kidneys, nerves and vascular system. The presence of an extensive microvasculature and abundant connective tissue raises the possibility that lung may also be a target organ in diabetes. Aims and Objectives: To compare and correlate diabetic nephropathy with parameters of diffusion capacity of lung. Methods: A total of 60 T2DM patients with or without complications of age group 35-55years and 60 age and sex matched control were included after inclusion and exclusion criteria. All subjects were evaluated for PFT with Diffusion capacity (DLCO) by single eath technique- INSPIRE HD –PFT) and status of nephropathy by microalbuminuria. DLCO was correlated with diabetic nephropathy. p<0.05 was considered as significant. Results: There was significant (P<0.05) changes in diffusion capacity (DLCO% and DL/VA%) in cases compared to controls and significant deterioration of diffusion of lung in Diabetic nephropathy(microalbuminuria) and that was negatively correlated with DLCO% (r=-o.53) and DL/VA% (r=-0.66) . Conclusion: There was significant impairment of diffusing capacity of lung in diabetic nephropathy cases compared to controls and also negative correlation found between microalbuminuria with diffusion capacity.