Demyelinating Lesions In Multiple Sclerosis: A Retrospective Study Of Mri Findings In Indian Population

ABSTRACT

Background: The MRI in Multiple sclerosis(MS) reveals focal white matter lesions which can show dissemination in space or in time. Therefore, the aim of this study was to determine the incidence and distribution of the white matter lesions on MRI.Methods: In this retrospective observational study MRI findings of all cases of MS diagnosed on the basis of McDonald criteria were studied.Results: The white matter lesions were most commonly seen in Periventricular region 43(66.2%) cases, followed by Centrum semiovale36 (55.4%). Subcortical and Juxtacortical lesions were seen in 12 (18.4%) and 20 (30.7%) cases respectively. Optic nerve involvement was seen in 4(6.1%) cases. The spinal cord was affected in 30 (46.1%) cases. Black holes were seen in only 3 (4.6%) cases and contrast enhancement in the lesions was seen in 30 (46.1%) cases.Conclusion: By mapping out the distribution and incidence of lesions in MS on MRI this study will help in correctly identifying demyelinating lesions which can b confused with other hyperintense lesions on T2Wimaging.