A Study Of Serum Ck–Mb Level In Non Dialysed Chronic Kidney Disease Patients

ABSTRACT

Chronic kidney disease is associated with early increased risk of cardiovascular morbidity and mortality. CK–MB the traditional marker for myocardial ischemia loses its specifity in renal failure because of non cardiac source of this enzyme. AIMS: The aim of the study was tomeasure and compare the level of serum CK–MB innon dialysed chronic kidney disease patientsand in healthy controls. MATERIAL AND METHOD 50 healthy controls and 50 non dialysed chronic kidney disease patients on conservative treatmentattending Nephrology department, Gauhati Medical College and Hospital, during September 2015–August 2016 were included in this study. Quantitative analysis of urea, creatinine, CK–MB were done by photometric method. RESULTS Serum CK–MB levels were significantly higher in the cases as compared to controls (p value <0.0001). CONCLUSION Non specific modest elevation of CK–MB can cause false positive results in absence of myocardial ischemia in CKD patients. So CK–MB should be interpreted with caution in these patients.