Gall Bladder Metaplasia: Its Prevalence And Correlation With Dysplasia And Carcinoma

ABSTRACT

Background: Gallstones are the most common biliary pathology. Gall bladder metaplasia has been cited as precursor lesion of dysplasia and therefore carcinoma. The aim of study was to assess the prevalence of gallbladder metaplasia due to underlying cholelithiasis and to establish its correlation with dysplasia and carcinoma. Materials and methods: All the post cholecystectomy samples during 1 year period from October 2017 to September 2018 submitted for histopathology comprised the study material. Results: Total 359 cases were included, of which metaplasia was seen 152(42.3%). Antral metaplasia is commonest 104 (29.0%) followed by combined metaplasia cases 34 (9.5%) and than intestinal only cases in 14(3.9%). Significant correlation was seen between intestinal metaplasia to antral metaplasia and dysplasia. Conclusion: Very high prevalence of metaplasia was observed. Antral metaplasia was more frequent than combined metaplasia followed by intestinal alone. Intestinal metaplasia was statistically correlated to dysplasia.