A Comparative Study Of Effects Of Clonidine And Magnesium Sulphate On Propofol Requirement In Craniotomy Patients Under General Anaesthesia

ABSTRACT

Introduction:Awareness can be defined as the subjective experience of external or internal stimuli. Recent review of reported cases of awareness suggested the absence of volatile agents or intravenous agents during maintenance of anaesthesia 2. Material & Methods:The study was conducted in SMS Medical College and attached hospital, Jaipur after approval from the institutional ethics committee. The present study was conducted in 105 patients 35 in each group of ASA physical status 1 & 2 posted for elective spinal surgery under general anaesthesia, age between 20-50 years, Hospital – based, randomized, double blind, comparative interventional study. The sample size was calculated 35 subjects in each group. Results: In recovery period, the time to reach BIS to 80 was found to be significantly more in Group B compared to Group C and Group A [P<0.001]. When the groups were compared, all the three parameters of recovery (extubation time, response to verbal commands and time for orientation) were found to be significantly longer in Group B. There were no significant difference between the other two groups, i.e. Group Aand Group C (P< 0.001).Propofol Induction and Maintenance dose found to be significantly more in Group C as compared to group B than Group A. (P < 0.001). Total Propofol requirement was significantly more in group C as compared to group B than Group A. (P< 0.001). Conclusion: Perioperative use of both clonidine and magnesium sulphate significantly reduced the requirement of propofol. They were able to attenuate the haemodynamic response to tracheal intubation. Clonidine was associated with bradycardia and hypotension. Magnesium sulphate caused a delay in recovery.