A study of Anti Nuclear Antibody (ANA) in collagen vascular diseases
Article
| IMSEAR
| ID: sea-186499
ABSTRACT
Background:
The diagnosis of collagen vascular disease is based on clinical, serological and histological findings. The classical ANA indirect immunofluorescence assay is the most efficient screening test for LE. Aim andobjectives:
To study ANA profile in various collagen vascular diseases. Materials andmethods:
A study was conducted in 170 clinically confirmed cases of collagen vascular diseases during 2010-2012. A thorough clinical examination was carried out and baseline investigations were done. All the patients were subjected to complete ANA profile. Patients were followed up regularly in department of dermatology.Results:
Majority of the patients (55%) in our study were those of lupus erythematosus and systemic sclerosis (30%). The study revealed that 92% patients of SLE, 90% of MCTD, 85% of systemic sclerosis and 50% each of dermatomyositis and overlap syndromes showed ANA positivity. 77.14% and 42.85% patients of SLE showed anti Ds DNA and anti Ro 52 positivity respectively. Anti scl 70 positivity was seen in 75% patients of systemic sclerosis. All patients of MCTD tested positive anti u1 RNP.Conclusion:
ANA profile correlated very well with clinical manifestations in majority of patients in this study.
Full text:
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Index:
IMSEAR (South-East Asia)
Year:
2016
Type:
Article
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