Clinical outcome and response of treatment in asymptomatic bacteriuria in type I and type II diabetes in women

ABSTRACT

Back Ground Asymptomatic bacteriuria is common in neonates, preschool children, in pregnant women, in elderly people, in diabetes mellitus, in catheterized patients and in patients with abnormal urinary tracts or renal disease. Few data, however, are available about the potential complications arising from asymptomatic bacteriuria for various populations and for various medical conditions. The aim of the study To study clinical outcome and response of treatment in asymptomatic bacteriuria in Type 1 and Type II Diabetes in women. Materials and methods: 150 Diabetes mellitus patients without any urinary complaints such as dysuria, frequency, urgency, strangury, tenesmus, nocturia, nocturnal enuresis, incontinence, urethral pain, bladder pain, renal colic, who attended Diabetology Department as outpatients and in patients in various wards of Govt. Government Mohan Kumuramanglam Medical College, Between 2015- 2016 were enrolled for this study. Results: 30% of the culture-positive cases occurred in 1 to 3 years duration group 24% of positive cases occurred in 5 to 10 years duration group. Of the 15 new cases, 5 cases were culture positive; the percentage of culture positive in new cases was 33.33%. 40% of culture-positive cases had random blood sugar value in the range of 201 mg% to 250 mg%. 24% of cases had random blood sugar value in the range of 151 mg% to 200 mg%. 15% of patients had a random blood sugar range of 251 mg% to 300 mg%. Of the 6 patients with diabetic nephropathy, 4 cases were culture positive, the positive culture percentage was 66.66%. Both cases of diabetic retinopathy are culture was positive. Both cases were grown E.coli. Of the 4 cases with ischemic heart disease, 2 cases were culture positive. S. Palanivel Rajan, I.V. Priyamvadha. Clinical outcome and response of treatment in asymptomatic bacteriuria in type I and type II diabetes in women. IAIM, 2019; 6(4) 26-30. Page 27 E.Coli was grown in culture positive cases in the study group was mostly highly sensitive to quinolones viz norfloxacin and ciprofloxacin and gentamicin. Other commonly used antibiotics like tetracycline, ampicillin, co-trimoxazole, cephalexin, nalidixic acid etc. were non-sensitive to E.coli. Klebsiella were grown in culture positive cases in the study group were 100% highly sensitive to quinolones. Conclusion: Quinolones are used widely for the treatment of E coli causing UTIs and may also be used to treat other infections caused by other members of the Enterobacteriaceae family. There has been a significant increase in quinolone-resistant uropathogenic E. coli strains isolated from patients with UTI in several countries and therapeutic failures have been reported