A study of prevalence of microalbuminuria in non-diabetic non-hypertensive coronary artery disease

ABSTRACT

Background: Microalbuminuria is a marker of widespread vascular damage in diabetic as well as non-diabetic patients. However, more and more evidence is accumulating that microalbuminuria is an important cardiovascular risk factor even in the general population. Its early detection helps in preventing the progression of cardiac decompensation. Aggressive treatment of microalbuminuria is associated with improved renal and cardiac functions. Aim of the study To find out the prevalence of microalbuminuria in non-diabetic and nonhypertensive patients with coronary artery disease. Materials and methods: Prospective nonrandomized case series was done in the Department of General Medicine, GAAMCH, Karapettai, Kanchipuram in the year 2017. In this 50 non-diabetic and non-hypertensive CAD patients were selected from those admitted in General Medicine ward. Data collection was by clinical history, examination and investigations such as blood investigations- fasting blood sugar, blood urea, serum creatinine, serum electrolytes, fasting lipid profile, urine albumin, and deposits, chest X-ray PA view, ECG, Echo were done and reports were analyzed thoroughly. Results: Among the males, 94.3% were smokers and 5.7% were non-smokers. 100% of women were non-smokers. There were 12 patients with abnormal total cholesterol, out of which 10 patients (83.33%) had microalbuminuria and out of 38 patients (73.68%) with normal total cholesterol, 28 had microalbuminuria. The observation showed that there was no significant association between total cholesterol and microalbuminuria (P>0.05). Namashivayam Shanmugasundram, Raja Ponnusamy. A study of prevalence of microalbuminuria in non-diabetic nonhypertensive coronary artery disease. IAIM, 2019; 6(4) 31-35. Page 32 Conclusion: Among the 50 non-diabetic non-hypertensive CAD patients, 38 patients (76%) had microalbuminuria. Microalbuminuria is positively associated with the ischemic heart disease in nondiabetic non-hypertensive CAD patients and can be regarded as an additional risk factor for ischemic heart disease. Hence screening for microalbuminuria is a worthwhile public tool for cardiac risk stratification and targeting preventive strategies.