A study on adverse drug reaction associated co-morbid symptoms on newly diagnosed TB patients with and without diabetes mellitus

ABSTRACT

Background: The incidence of Tuberculosis and severity increased in immunocompromised state like Diabetes mellitus. When combined with ATT and antidiabetic drugs, the adverse reaction are increased. Aim of the study To study the incidence of adverse drug reaction associated co-morbid symptoms on newly diagnosed TB patients with Diabetes Mellitus. Materials and methods: 100 cases of newly diagnosed sputum positive pulmonary tuberculosis (50 diabetic and 50 non -diabetic) fitting the inclusion criteria admitted over the period of 2 years from 2016-2017. Subjects were selected from medicine ward, pulmonology ward and Tuberculosis ward under DTC. The diagnosis of Pulmonary tuberculosis was made with clinical presentation and verification by detection of acid fast bacilli under microscope. Results: Among the diabetic population, 28 (28.00%) were received biguanides, 10 (10.00%) were received insulin, and 12 (12.00%) were received sulphonylureas. Among the study population, 28 (28.00%) had peripheral neuropathy, 25 (25.00%) had liver injury, 4 (4.00%) had hypoglycemia, 11 (11.00%) had back pain, and 52 (52.00%) had nausea vomiting. Conculsion When treating patients with diabetes and TB, there is increased incidence of polyneuropathy and liver toxicity