Estimated glomerular filtration rate and proteinuria – Predictors of left ventricular mass in chronic kidney disease

ABSTRACT

Background: Chronic kidney disease is a potential threat of the 21st century, afflicting more than 50 million people all over the world. Cardiovascular diseases particularly increased left ventricular mass accounts for 40 – 50% deaths of kidney disease patients. Objective of the study To find the factors which correlate with left ventricular hypertrophy in kidney disease patients. Materials and methods: A descriptive study was done on 75 chronic renal failure patients for a period of 6 months. Variables like proteinuria, creatinine clearance, anemia, blood pressure, serum albumin and other blood parameters were compared with left ventricular mass. Results: Of all the variables, the decline in estimated glomerular filtration rate and the increased amount of protein excretion affected the left ventricular mass index (p < 0.01). The mean GFR was 25 ml/min and the mean proteinuria > 3.5 g in females with left ventricular hypertrophy (>110 g/m2 ). With the cut-off for left ventricular hypertrophy in male > 134 g/m2 , the mean GFR was 20 ml/min and the mean proteinuria more than 7 g/L. Conclusion: Measures to decrease the amount of proteinuria and the rate of decline in glomerular filtration rate will prevent significant cardiovascular disease in chronic kidney disease patients.