Prevalence of metabolic syndrome in euthyroid patients in Perambalur District

ABSTRACT

Background: Euthyroid diseases are frequently observed in clinical practice. They comprise both functional abnormalities such as overproduction and underproduction of thyroid hormone as a consequence of intrinsic thyroid diseases, as well as the development of structural abnormalities like goiter, adenoma or carcinoma. In community surveys, prevalence rates of elevated TSH levels – indicating impaired thyroid hormone secretion – range from 4–10% while prevalence rates of decreased TSH levels – indicating thyroid hormone overproduction – range from 0.7–1.5 %. Aim of this study To assess the thyroid function, in euthyroid subjects, is associated with components of the metabolic syndrome parameters. Materials and methods: The study was conducted in the Department of Biochemistry at Dhanalakshmi Srinivasan Medical College and Hospital, Siruvachur, Perambalur District, Trichy. Total of 100 cases was included in the study homeostasis model assessment for insulin resistance (HOMA- IR) metabolic syndrome was defined according to the national cholesterol education program’s adult treatment panel III criteria. Results: The T4 (FT4) was significantly associated with total cholesterol (standardized beta (β) = - 0.059; P = 0.014), low-density lipoprotein cholesterol (β = -0.068; P = 0.004), high-density lipoprotein cholesterol (β = 0.100; P < 0.001), and triglycerides (β = -0.102; P < 0.001). Both FT4 and TSH were significantly associated with HOMA-IR (β = -0.133; P <0.001 and β = 0.055; P = 0.024, respectively). Median HOMA-IR increased from 1.42 in the highest tertile of FT4 to 1.66 in the lowest tertile of FT4. FT4 was significantly related to four of five components of the metabolic syndrome (abdominal obesity, triglycerides, high-density lipoprotein cholesterol, and blood pressure), independent of insulin resistance.