The Role of TNF-Alpha, Beta, XRCC1 and p53 Gene Predisposition in Cancers

ABSTRACT

Cancer is a group of diseases characterized by abnormal and uncontrolled cellular growth and differentiation. The major cause of Cancer consists of different types of genetic alterations that include gene substitutions, point mutations and gene amplification leading to damage in molecular pathways responsible for cell growth, survival, and metastasis. These changes develop in the majority of cases with a specific type of tumor. Genes can be used as biomarkers for identification and development of targeted treatments and also for predicting various responses to therapies. The aim of the present review is to reveal the role of tumorigenesis in TNF alpha, beta, xrcc1 and p53 genes in cancer susceptibility to gene predisposition.