Efficacy of serum sialoglycoproteins as a biomarker of the disease activity & treatment monitoring in patients with base tongue malignancy.
Article
in English
| IMSEAR
| ID: sea-18803
ABSTRACT
Serum levels of sialoglycoprotein constituents i.e., sialic acid, seromucoid hexoses, and mucoid proteins were determined in 34 patients with base tongue malignancy and 15 controls matched for age and sex. All three constituents were found to be significantly raised; however, only sialic acid levels increased with the severity of the disease. More than 92 per cent of the patients in each clinical stage showed abnormal values of hexoses and mucoid proteins in seromucoids. Electrophoretic separation showed a split in alpha-2-glycoprotein at pretreatment time in 67.6 per cent of the patients. On administration of radiotherapy, all three fractions decreased while alpha-2- split disappeared in 61.8 per cent patients and gamma glycoprotein peak emerged at the end of the protocol with a parallel decrease in these three constituents. It may be concluded from the data that serum sialoglycoproteins can be useful to monitor therapy in base tongue malignancy patients.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Sialoglycoproteins
/
Female
/
Humans
/
Male
/
Tongue Neoplasms
/
Biomarkers, Tumor
/
Monitoring, Physiologic
/
Neoplasm Staging
Type of study:
Practice guideline
Language:
English
Year:
1989
Type:
Article
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