Observations On Haemodynamic Effects Of Sevoflurane – Propofol Co-Induction

ABSTRACT

Background: Both Propofol and Sevoflurane have been seen to decrease the haemodynamic stress response obtained with oro-tracheal instrumentation. But they are also associated with significant depression of cardiovascular system. With the aim to gain benefit from both these agents but lessen the cardiovascular depressive manifestations, we induced the patients using both the agents in decreased dosages and observed the effects there upon on haemodynamic parameters. Methods: 30 patients were given to inhale Sevoflurane(4%) in Oxygen and were also administered intravenous Propofol (1mg/kg) for induction of general anaesthesia. Aided by IV SuccinylCholine(1mg/kg), trachea was intubated under direct laryngoscopy. Results: The Systolic , Diastolic, Mean Blood Pressure values and Pulse rates were noted before and after induction and following intubation and the observations were analysed. Conclusion: .Anaesthesia induction with Propofol and Sevoflurane combination blunts the haemodynamic stress response.