A Study of Acute Febrile Illness with Thrombocytopenia from Tertiary Care Centre of Uttarakhand

ABSTRACT

Background:Acute febrile illness with thrombocytopenia is a common condition that is associated with an increased risk of morbidity and mortality. Infection is a common cause of thrombocytopenia. Infections like Malaria, Dengue, Typhoid and septicaemia are some of them. The present study is intended to know the various clinical presentation, laboratory studies, aetiology, clinical complications, relationship between platelet count and severity of disease and prognosis associated with acute febrile illness and thrombocytopenia. Material and Methods: Total 200 patients of age more than 12 years with acute febrile illness with thrombocytopenia attending medicine department were enrolled and studied for demographic details, clinical presentation and complications. Results: Majority of patients were aged <40 years (66.0%) with males (72%) preponderance. Out of total 200 cases enrolled in this study, 82 cases (41%) were diagnosed as dengue fever, 60 cases (30%) were of malaria, 36 cases (n=36;18%) were of scrub typhus, 6 cases (3%) were of Septicemia, 5 cases (n=5;2.5%) were of typhoid fever and 11 cases(5.5%) remain undiagnosed. Conclusion: Dengue was the commonest cause of fever with thrombocytopenia. Common Bleeding manifestations were petechiae /purpura and gum bleeding. Thorough clinical and laboratory evaluation would be helpful to evaluate different causes of fever with thrombocytopenia.