Effect of hormones on Serum Lipid Lipoprotein Profile in Females of Reproductive Age Group

Background:Oral contraceptives can induce changes in lipid, lipoprotein and carbohydrate metabolism. This study is done to find out basal lipid profile in females of reproductive age group using sequential hormone therapy and with low dose estrogen combinations pills; and to study the changes in lipid profile after 3 months use of sequential hormone therapy and with low dose estrogen combination pills. Methods: Total 40 females were taken of 18-40years of reproductive age group ,subjects were divided into two groups. Group A: 20 females were subjected to sequential hormones therapy. Group B: 20 females were subjected to combined oral contraceptive pill “Mala N”. Results: In Group A there was significant rise in serum cholesterol, serum TGs ,LDL, VLDL levels and LDL:HDL ratio. HDL shows fall in there levels. In Group B there was no significant change in all lipid parameters. Conclusion: There is substantial degree of metabolic changes in lipid lipoprotein profile in females with use of sequential hormones .With use of low dose estrogen and progesterone pills, there is no such deleterious effect on lipid profile and so it can be used for prolonged period. As the indications of use of sequential hormones in females of reproductive age group are now increasing in gynecological practice it would be advisable to decrease the dose of estrogen to avoid its effects on lipid profile