Effect of New Onset Diabetes after Transplantation (NODAT) On Graft Survival in Renal Transplant Recipients

ABSTRACT

Background:Newonset diabetes after transplantation (NODAT) refers to diabetes that occurs in previously nondiabetic persons after solid-organ transplantation, bone marrow and hematopoietic stem cells. New Onset Diabetes After Transplantation (NODAT) is one of the metabolic complications after kidney transplantation which affects adversely the allograft kidney and patient outcomes. Methods: This study was conducted in Department of Nephrology at Sher I Kashmir Institute Of Medical Sciences (SKIMS ) , a tertiary care center in Srinagar , Jammu and Kashmir , India, between July 2013 to June 2016.All the patients who underwent renal transplantation during this period in our institute were enrolled in this study.In the post renal transplant period , patients were classified as those who developed NODAT and as normal patients. Effect of NODAT on the graft survival was studied by comparing the serum urea, creatinine and urinary protein between the NODAT and the normal patients. Results: A total of 100 patients of End Stage Renal Disease (ESRD) who underwent renal transplantation in department of nephrology were enrolled in our study.Out of 100patients, 79 were males and 21 were females. A total of 17 patients developed NODAT in our study. It was observed that the patients developing NODAT in post renal transplantation period were having a higher values of serum creatinine and urea as compared to normal patients. Moreover proteinuria was more commonly present in NODAT patients than normal patients. Conclusion: The development of NODATis associated with a poor graft function in the post transplant period.