Clinical Profile of Hepatitis B Positive Cases Presenting at a Tertiary Care Hospital in Kumaon Region of Uttarakhand

ABSTRACT

ackground HBV is one of the main causes of end stage liver disease and hepatocellular carcinoma (HCC). The clinical presentation ranges from asymptomatic or inapparent infection to acute liver failure. Chronic liver disease with cirrhosis and hepato-cellular carcinoma are the other spectrum of the disease. Method: All the patients diagnosed with hepatitis B surface antigen (HBs Ag Positive) presenting with or without symptoms and signs of hepatitis B infection were included in study. Result: The age of the patients varied from 15-75 years. 60% patients are male, majority (55.5%) are married, 40% are secondary educated, 47% are labour class, 69% of patients having unknown sources of infection. Majority of patients were presented with symptoms and only 27% were asymotomatic on presentation. Major symptom were abdominal discomfort, fever and fatigue. 65% patients having icterus, 55.5% hepatomegaly and 35% patients having no any clinical signs. Serum bilirubin and alanine transaminase (ALT) level were significantly higher in symptomatic patients (60%). 13% patients shows portal hypertention and 22% shows ascites on ultrasonography. Conclussion The majority (65.45%) of patients were in younger age group 15-45 years, majority are male(60%), married (55.5%), labour class (47.3%) .The risk factor as related to HBsAg positivity was because of unknown source 76 (69.09%) cases followed by history of previous surgery 14 (12.7%) cases