Observation of Serum Lipid Profile and hsCRP in Prediabetic Population

ABSTRACT

Dyslipidemia and raised serum hsCRP level occurring in diabetic patients, play an important role in development of macrovascular and microvascular complications as compared to nondiabetics. Keeping in view the prevalence and increased risk of multiorgan involvement in diabetes, it is imperative to diagnose prediabetic individuals and assess their serum lipid profile and serum hsCRP level and Use of these biomarkers as a preventive measure from the complications of prediabetes, developing overt diabetes and increased morbidity and mortality. Aim: observation of serum lipid profile and hsCRP in prediabetic population. Methods: Prospective cross-sectional case control observational studycarried out between august 2017- November 2018 (16 months) which included 100 cases (prediabetics) and 100 controls (nondiabetics). Lipid profile and serum hsCRP level of all prediabetic individuals and nondiabetics was done and statistically analyzed. Results: Serum Total cholesterol, triglyceride (TG), low density lipoprotein (LDL) and serum hsCRP level were significantly raised in prediabetic individuals as compared to nondiabetics, whereas high density lipoprotein (HDL) was nonsignificantly lower and mean with SD was much lower side in prediabetic individuals as compared to nondiabetics. Conclusion: Prediabetics had altered lipid profile as compared to nondiabetics. These prediabetic individuals, because of their raised hsCRP level and dyslipidemia, are at higher risk for developing cardiovascular disease and other multiorgan involvement. So to halt progression by primary prevention as Lifestyle modification or pharmacotherapy in such individuals becomes animportant public health consideration.