A Prospective Study of Thyrotoxicosis Clinical Presentation and Etiopathogenesis

ABSTRACT

Thyrotoxicosis denotes the clinical syndrome that results from tissue exposure to excess circulating free thyroid hormones e thyroxine (3,5,30 ,50 -tetraiodo-L-thyronine; T4) and/or triiodothyronine (3,5,30 -triiodo-L-thyronine; T3). Aim: To study the clinical presentation and etiopathogenesis of thyrotoxicosis. Methods: Thyroid profile, x-ray neck and ECG were taken for the cases. Radio-Isotope study was not done since facilities are not available in our hospital. Surgery was the modality of treatment offered to all patients. Results: Most of the patients who were diagnosed to have thyrotoxicosis were in the age group 31-45 years. The incidence of thyrotoxicosis in females was high and the male. All the patients had a goiter. The most significant clinical features were palpitation, weight loss, diarrhea, sleep disturbances, excitability and heat intolerances in the order of frequency. Conclusion: From the evidence it is clear that after adequate control of toxicity with anti-thyroid drugs, surgery is the modality of treatment that can be safely offered to patients with thyrotoxicosis.