Effect of Prior Administration of Butorphanol and Lidocaine on Pain during Propofol Injection

ABSTRACT

The aim of this study was to investigate the effect of prior administration of butorphanol, lidocaine and normal saline in minimizing Propofol injection pain. Methods: The study comprised of 99 patients divided into three groups of 33 each, in the department operation rooms of Anaesthesiology/Surgery, State Referral Hospital of Zoram Medical College, Falkawn, Mizoram during the period of March 2017 to April 2019. Ninety nine patients of ASA grade I and II, aged between 18 and 60 years of both sexes scheduled to undergo major elective surgery under general anaesthesia were included. Results: Pain on intravenous injection of propofol was experienced by 9 (27.27%) patients from butorphanol group as compared to 18 (54.55%) and 22 (66.67%) patients in the lidocaine and placebo groups respectively. Data analysis showed a chi-square test value of 15.3 and p-value 0f <0.05. Conclusion: The present study shows that prior administration of butorphenol significantly reduced pain on intravenous injection of propofol whereas lidocaine pretreatment too reduces propofol injection pain as compared to a placebo, but failed to show statistically significant results.