The Study of the Role Polymorphism of the P2RY12 Gene rs 2046934 in the Pathogenesis of Disaggregation Thrombocytopathy

ABSTRACT

Thrombocytopathy (TP) is one of the dangerous pathologies related to the platelet’s function; widespread of them is disaggregation thrombocytopathy. Authors aimed to study the role of polymorphism of the P2RY12 and rs2046934 genes in the formation of individual accident of Uzbek nationality. Methods: The study was conducted (n=71) patients with disaggregation thrombocytopathy, which was observed in consultative outpatient clinic of Institute of Hematology and blood transfusion Ministry of health Uzbekistan. Results: the study showed that the unfavorable allele A association with risk of development of hemorrhagic syndrome in disaggregation thrombocytopathy. Conclusions: The frequency of A/A and G/A genotypes of the P2RY12 gene in our sample was somewhat comparable with the world data and is consistent with the assumption that they affect the development of hemorrhagic states in disaggregation thrombocytopathy