Effect of a Single Pre-Operative Dose of Dexmedotomidine Versus Fentanyl on Anesthetic Requirement and Peri- Operative Hemodynamic Stress Response

ABSTRACT

Background: Dexmedetomidine has sympatholytic, ant nociceptive, sedative, and anti-sialagogue properties without causing respiratory depression. Dexmedetomidine is the active d-isomer of medetomidine, that is a selective and specific α2-adrenoceptor agonist. It acts by the central sympatholytic action. So it provides haemodynamic stability. It has both analgesic as well as anaesthetic sparing property. Dexmedetomidine is also an effective sedative. Methods: Study Population- Two groups were included in this study.49 cases were included in group II & 50 cases were included in group II.The duration of study was over a period of 6 month.This study was conducted in the Department of Anesthesia in Carrier Institute of Medical Sciences, Lucknow. Results: This result revealed that adverse effect of bradycardia was seen only in one patient. None of the patients was sedated after discontinuation of anesthesia. Conclusion: This study concludes that, during laryngoscopy and in the perioperative period, a single pre-operative dose of Dexmedetomidine provides better hemodynamic stability in comparison to Fentanyl by attenuation of sympathoadrenal response.