Molecular abnormalities of bcr gene in some Indian patients with chronic myeloid leukaemia.
Article
in English
| IMSEAR
| ID: sea-18921
ABSTRACT
The DNAs from 7 unselected Philadelphia chromosome-positive (Ph') chronic myeloid leukaemia (CML) patients were analysed for the distribution of breakpoints in the breakpoint cluster region (bcr) gene by Southern blot. Breakpoints were detected between the regions of exons '2' and '4' of the bcr gene in 5 out of 7 patients. In two patients, breakpoints occurred around exon 4 of the bcr gene. This study presents some information on the nature of breakpoint distribution in the bcr gene of Indian CML patients.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Philadelphia Chromosome
/
Female
/
Humans
/
Male
/
Gene Rearrangement
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Child
/
Chromosome Aberrations
/
Fusion Proteins, bcr-abl
/
Adult
Country/Region as subject:
Asia
Language:
English
Year:
1996
Type:
Article
Similar
MEDLINE
...
LILACS
LIS