To Study The Prevalence of HPV Genome in HIV Positive Women in Comparison to HIV Negative Women in India

ABSTRACT

Cervical cancer is the second most common cancer among women worldwide. Infection with the Human Immunodeficiency Virus (HIV) is associated with an increased risk of prevalence of HPV. Cervical cancer is most common in age group 45-55 years. The various risk factors include age at first intercourse, multiple sexual partners, use of oral contraceptives pills, parity, family history, associated genital infections, and immunosuppression etc. Sexually transmitted human papilloma virus (HPV) infection is the most important risk factor for cervical intraepithelial neoplasia and invasive cervical cancer. Objective: To study the prevalence of HPV in the study group comprising of 100 HIV positive women and 100 HIV negative women. Methods: The present study was conducted in the department of Pathology, GMC, Patiala on 100 cervical brushings prepared from HIV positive patients attending ART Centre and 100 HIV negative femalesat GMC andRajindra hospital, Patiala. The cervical brushings were analysed in the Department of Pathology, Government Medical College Patiala. HPV detection was done on samples of cervical brushings. Results: In the 200 cases studied, 74 cases were positive for HPV infection. Out of 74 cases, 51 (51%) cases were HIV positive and 23 (23%) cases were HIV negative. Conclusion: It was seen that prevalence of HPV was higher in HIV positive cases as compared to HIV negative cases.