Association of Vitamin B12, Folate and Ferritin with Thyroid Hormones in Hypothyroidism

ABSTRACT

Thyroid hormones are required for normal development as well as regulating metabolism in the adult. Thyroid gland disorders are the second most abundant endocrinal disorders after diabetes. A decreased thyroid hormone adversely affects erythropoietic system causes anaemia. Aim: The Aim and objective of the study was to compare the vitamin B12, Folate and Ferritin with thyroid hormones in hypothyroidism. Methods: In the present study, total 350 samples were included in which 175 were hypothyroid patients and 175 were normal individuals of age group between 15-65 years. Measurements of serum concentrations of Total T3, Total T4, TSH, Vitamin B12, Folate and Ferritin were done using Chemiluminiscence Immunosorbant Assay. Results: Serum TSH levels were significantly increased in Hypothyroidism as compared to normal individual (7.42±1.75 vs 2.72±1.28, p<0.0001*). The total T3 level was significantly decreased in Hypothyroidism in comparison to normal individual (0.43±0.41 vs 1.30±0.29, p<0.0001*). Similarly, total T4 level was significantly decrease in Hypothyroidism in comparison to normal individual (3.60±1.38 vs. 6.62±1.11, p<0.0001*). Level of Vitamin B12 was significantly decreased in Hypothyroidism in comparison to normal individual (210.45±129.30 vs 483.93±264.74, p<0.0001*). Folate was significantly decreased in Hypothyroidism as compared to normal (2.51±0.99 vs 6.67±0.83, p<0.0001*). Ferritin was also observed significantly decreased in Hypothyroidism in comparison to normal (23.08±1.18 vs 63.43±3.30, p<0.0001*). TSH was observed significantly correlated with Folate (r=0.187* p=0.013). Conclusion: The Lower values of above these parameters in hypothyroidism interpret that thyroid hormones are metabolic hormones and produce impact on our metabolic and hormonal balance in which hemopoetic system is highly effected.