Second primary malignancies in laryngeal carcinoma patients treated with definitive radiotherapy
Indian J Cancer
;
2018 Jan; 56(1): 29-34
Article
| IMSEAR
| ID: sea-190294
ABSTRACT
INTRODUCTION:
Second primary malignancy (SPM) is associated with decreased overall survival (OS) in laryngeal carcinomas (LC).METHODS:
One hundred eighty three LC patients were analyzed retrospectively. The primary and secondary endpoints were the incidence of SPM and the OS difference between patients with and without SPM.RESULTS:
SPM developed in 22 (12.0%) patients at median 52 months (range, 4–131 months), with a yearly 2.8% incidence, of which 19 (10.4%) and 3 (1.6%) were metachronous and synchronous, respectively. Lung was the commonest SPM (72.7%). Of 47 deaths, 12 (25.5%) were SPM related. Comparatively SPM patients had significantly shorter median OS (68.0 months vs. median not reached; P = 0.005), with lower 5-year (67.0% vs. 78.9%) and 8-year (32.6 vs. 69.8%) survival rates.CONCLUSION:
The present findings suggested the SPM as a competing risk factor for death in index LC patients with its annual incidence rate of 2.8% and for accounting one of every four deaths in this patients group. Emergence of lung carcinoma as the most frequent type of SPM and the ability to treat >50% of them with an estimated long-term outcomes emphasizes the importance of early diagnosis and curative treatment of SPMs.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Risk factors
/
Screening study
Journal:
Indian J Cancer
Year:
2019
Type:
Article
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