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Correlation between human leukocyte antigen-G expression and clinical parameters in oral squamous cell carcinoma
Indian J Cancer ; 2018 Oct; 55(4): 340-343
Article | IMSEAR | ID: sea-190386
ABSTRACT

BACKGROUND:

Human leukocyte antigen-G (HLA-G) is a tumor-associated molecule, whose expression may help the cancer cells to escape the immune response.

AIMS:

The aim of this study was to evaluate the diagnostic value of HLA-G level in oral squamous cell carcinoma (OSCC). MATERIALS AND

METHODS:

A total of 52 patients who had definite pathological diagnosis and 20 cases of healthy controls were enrolled in this clinical trial. Immunohistochemisty (IHC) and quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) analysis were considered for HLA-G identification and multilevel validations. Statistical analysis was performed using SPSS and statistical significance was determined at P < 0.05.

RESULTS:

IHC results demonstrated that the expression of HLA-G in OSCC was strongly positive and the rate of positive expression was 55.77% (29/52), but the expression of HLA-G in healthy controls was negative (0/20). Furthermore, RT-PCR results showed that the positive expression rate of HLA-G messenger RNA was weak in healthy controls, but strong in OSCC. Besides, HLA-G expression in the tumors was significantly correlated with histological grade.

CONCLUSIONS:

Our results suggested that HLA-G is associated with the prognosis of OSCC and may serve as a novel therapeutic target.
Full text: Available Index: IMSEAR (South-East Asia) Type of study: Controlled clinical trial Journal: Indian J Cancer Year: 2018 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Type of study: Controlled clinical trial Journal: Indian J Cancer Year: 2018 Type: Article