To Study The Pattern Of Vitamin D Levels In Newly Diagnosed Type 2 Diabetes Mellitus Patients

ABSTRACT

Background:Diabetes mellitus is a metabolic disease, linked to deficiency of insulin occurring really or relatively can have an effect on almost body’s every organ system. Untreated diabetes can lead to majority of the complications. Vitamin D, fat-soluble secosteroids, are related to absorption of calcium, iron, magnesium, phosphate and zinc at intestine level to be increased. Vitamin D deficiency, appears to be related to the process of initiating type 2 DM. Mild to moderate vitamin D deficiency has been postulated to be a risk factor for type 2 diabetes. AIM: The present study was conducted to study serum vitamin D levels in patients with recently diagnosed type 2 diabetes mellitus in comparison with controls of similar age and gender. Methods:A total of 100 patients were included in the study among which 50 patients were diabetic and 50 were age and gender matched healthy non-diabetic controls. Patients in the age group of 30-65 yrs., who were diagnosed with type 2 diabetes within last 6 months were included in the study. Patients with Diagnosed cases of Type 2 diabetes mellitus on treatment for more than 6 months, known case of Cancer/ liver /renal dysfunction, medication that affect vitamin D metabolism/its absorption (Phenytoin, Rifampicin, Isoniazid, Ketoconazole, Carbamazepine, Phenobarbitone, valproic acid, Primidone, Prednisolone, Dexamethasone, Efavirenz, Atorvastatin, Orlistat, Cholestyramine, Estrogen, Thiazides, Antacids, Verapamil), Type 1 diabetes mellitus, Patients on vitamin D Supplementation were excluded from the study. Result: Optimal Vitamin D2 level was found among none (0) and 36.0% (18) subjects with diabetes and without diabetes respectively, Insufficient Vitamin D2 level was found among 14% (7) subjects each with diabetes and without diabetes and Deficient Vitamin D2 level was found among 86.0% (43) and 50.0% (25) subjects with diabetes and without diabetes respectively. Conclusion: Vitamin-D deficiency/insufficiency is common among individuals with diabetes.