Haemostatic Disorders in Sickle Cell Disease Subjects in Nigeria: A Review of Literature

ABSTRACT

Background: Sickle cell disease (SCD) is an autosomal recessive disorder that is characterised with chronic anaemia and painful crisis. SCD is associated with hypercoagulability or prothrombotic state that can predispose to thromboembolic complications with increasing morbidity and mortality. Aim: This study aimed to show the various documented haemostatic disorders and possible thromboembolic complications among SCD subjects in Nigeria. Methods: A comprehensive literature search was performed using the internet search engines linked to academic databases including Pubmed, Google Scholar, Ebsco, Hinari, Scopus, etc. Studies involving hemostatic disorders in Nigeria were thoroughly searched, and the references of such articles were also searched for any probable relevant information. Findings and Conclusion: There is a paucity of information on this subject in Nigeria, and there are inconsistencies in the available studies. Haemostatic disorders in sickle cell disease are conditions that are associated with increased mortality and morbidity. Further research on the level of natural anticoagulant is required to verify the correlation between haemostatic disorders and thromboembolic complications in SCD subjects in Nigeria.