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Frusemide-induced diabetes mellitus in insulin pretreated rabbits as an experimental model.
Article in English | IMSEAR | ID: sea-19617
ABSTRACT
Single dose of frusemide 0.1 mg/kg orally was administered in 10 rabbits pretreated with soluble insulin 4 IU intravenously. Induction of diabetes after 24 h was confirmed by an increase in blood sugar and glucosylated haemoglobin and a decrease in serum insulin levels. Ten diabetic rabbits which received only frusemide without insulin pretreatment were used as controls, whereas equal number of insulin-pretreated rabbits receiving hydrochlorothiazide 250 mg/kg orally served as the positive control group. All biochemical parameters remained unaltered in the frusemide-treated test group as well as the positive control group after two weeks. The pancreatotoxic effect of frusemide may induce a stable hyperglycaemic state in rabbits which could lead to a useful diabetic model.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Premedication / Rabbits / Male / Administration, Oral / Diabetes Mellitus, Experimental / Furosemide / Insulin / Animals Language: English Year: 1993 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Premedication / Rabbits / Male / Administration, Oral / Diabetes Mellitus, Experimental / Furosemide / Insulin / Animals Language: English Year: 1993 Type: Article