Frusemide-induced diabetes mellitus in insulin pretreated rabbits as an experimental model.
Article
in English
| IMSEAR
| ID: sea-19617
ABSTRACT
Single dose of frusemide 0.1 mg/kg orally was administered in 10 rabbits pretreated with soluble insulin 4 IU intravenously. Induction of diabetes after 24 h was confirmed by an increase in blood sugar and glucosylated haemoglobin and a decrease in serum insulin levels. Ten diabetic rabbits which received only frusemide without insulin pretreatment were used as controls, whereas equal number of insulin-pretreated rabbits receiving hydrochlorothiazide 250 mg/kg orally served as the positive control group. All biochemical parameters remained unaltered in the frusemide-treated test group as well as the positive control group after two weeks. The pancreatotoxic effect of frusemide may induce a stable hyperglycaemic state in rabbits which could lead to a useful diabetic model.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Premedication
/
Rabbits
/
Male
/
Administration, Oral
/
Diabetes Mellitus, Experimental
/
Furosemide
/
Insulin
/
Animals
Language:
English
Year:
1993
Type:
Article
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