Protective effect of eucalyptus globulus extract on glufosinate ammonium -induced hepatotoxicity in wistar rats

ABSTRACT

The present study aims to investigate the hepatoprotective effect of Eucalyptus globulus extract against pesticide liver damage in comparison to silymarin, a classical antioxidant liver medicine. Liver damage was induced by oral administration of toxicant i.e. Glufosinate ammonium. The extent of damage was studied by assessing biochemical parameters and histopathological evaluations. The aqueous extracts of Eucalyptus globulus were administered respectively to the animals pretreated with pesticide and its effects on biochemical parameters were compared with standard drug silymarin (100mg/kg b.wt). Eucalyptus globules showed significant reduction of serum enzymes AST, ALT, ALP & Bilirubin (Aspartate Transminase, Alanine Transminase, Alkaline Phosphatase & Total bilirubin) when compared to control counterparts. The hepatoprotective effect of Eucalyptus globules was comparable with the standard drug silymarin and it was confirmed by histopathological findings. Moreover, these effects presented in a dose-dependent manner.The present study showed that aqueous extract of Eucalyptus globulus at the dosage level of 500 mg/kgb.wt may play a protective role against pesticideinduced hepatotoxicity