Comparison Of Morphological Characteristics Of Pituitary Gland Between The Different Age Groups

ABSTRACT

Background: The pituitary gland (PTG) size, shape will change according to the age in response to the changes inthe hormonal environment. Hence care should be taken while evaluating the PTG disorders. This present studyconducted to evaluate the morphological changes in PTG with relation to age.Materials and Methods: This study was conducted in the Department of Anatomy was approved by InstitutionalHuman Ethics Committee. A total of 73 PTG specimens were included in this study. They are divided in to sixgroups based on the age. G-I (Foetus), G-II (1-10 Y), G-III (11-30 Y), G-IV (31-50 Y), G-V (51-70 Y) and G-VI(Above 71Y). All the specimens were subjected for H&E stain. The slides were observed for morphological changes. The datawas expressed in MEAN±SD and Statistical Package for Social Sciences (SPSS 16.0) version used for analysis.Results: More number of males was in group-V and females in group-IV. Pars intermedia had maximum thicknessin foetal life. Basophilic zone was not seen in foetal life but it is more prominent in other age groups. Cellularityincreased as age progress. Pars anterior and nervosa showed more vascularity compared to interior. As ageprogress this vascularity is decreased.Conclusion: From the study observations it can be concluded that as age progress there is a significant changesin the PTG morphology. Knowledge about these changes can useful for the diagnosis and treatment of variousdisorders of PTG.