Comparative Morphological And Morphometrical Analysis Of Human And Porcine Mitral Valve

ABSTRACT

Introduction: There is increased incidence of heart valve diseases in recent years due to life style modifications.The mortality rates in the heart valvular diseases are kept in pace using various modes of treatments. One suchtreatment is valve replacement surgery. It’s done either by using mechanical valve prosthesis or tissue grafts. Thetissue valves prosthesis, harvested from porcine heart are called as xenograft and are increasingly used in valverepair surgeries. In the present scenario, there is less number of systematically analysed literatures availableon the comparative anatomy of human and porcine heart valves. Hence this study was carried out to acquireknowledge and to put forth some points to future research works on heart valves.Materials and methods: In this study, 20 formalin fixed porcine and human hearts were procured from slaughterhouse and cadavers respectively. The morphology and morphometry of mitral valve were observed and analysedusing spss software 20 version. All the dependent variables were compared using student t test and independentsample test.Observation and results: it was observed that the mean circumference of the human mitral valve was 82.31mmand that of the porcine was 78.79 mm. The rough zone and clear zone was more prominent in porcine heart valvesthan the human heart valves. It was observed that the mitral valve of the porcine resembles the human heartvalve in morphology and morphometrical values were coinciding to their maximum.Conclusion: The porcine valve resembles human heart valves in morphology and it can be used in designing valvesubstitutes in replacement surgeries. Porcine valve can also be used as bio-prosthesis by matching themorphometry and by reducing the geometrical difference to their minimum by using any modes of interventionalradiology