Histomorphometric changes of gonads in male guinea pigs after thymectomy

ABSTRACT

Introduction: The presence of the thymus gland during early life is essential for the normal development ofimmune system and as well as proper maturation of the hypothalamic – pituitary- gonadal axis. This study wasto investigate the influence of thymus gland on male reproductive function.Aim: The aim of this study to investigate the effect of thymectomy on Morphometric changes of gonads inneonatal, prepubertal and pubertal thymectamized male guinea pigs.Material and Methods: In this study, a total of thirty male guinea pigs, thymectamized (n-6) and sham-operated(n-4) were studied in each group. The comparison of diameter of seminiferous tubules, luminal diameter andepithelial thickness in the thymectamized and sham operated male guinea pigs.Results: No Significant changes in the morphometry of seminiferous tubules of testis in thymectamized maleguinea pigs compared to the sham-operated guinea pigs in all age groups. These results suggest that thymectomyhad no detrimental effects on reproductive system in males at any intervals.