Lupus Nephritis in Indian Children: Flares and Refractory Illness
Indian Pediatr
;
2018 Jun; 55(6): 478-481
Article
| IMSEAR
| ID: sea-198983
ABSTRACT
Objective:
To evaluate the incidence of flares and treatment resistance in children with lupusnephritis and their association with renal outcomes.Methods:
We retrospectively reviewedthe case records of 34 children treated for lupus nephritis (Class II-IV) at a single center.Patients were followed for a minimum of five years to evaluate treatment response, onset offlares, and renal survival. Regression analyses were performed to identify the factorsassociated with treatment refractoriness, incidence of flares and renal survival.Results:
Theincidence of flares was 0.16 episodes/person/year. Eight patients (23.5%) were refractory totreatment. The five-year renal survival was 79%. Multiple episodes of flares (P=0.028) andtherapy refractoriness (P=0.003) were associated with poor renal survival.Conclusions:
Prevention and aggressive management of renal flares is expected to prevent progression toend stage renal disease in lupus nephritis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Prognostic study
Journal:
Indian Pediatr
Year:
2018
Type:
Article
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